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Salamander, Greater: an amphibian preferring warm to temperate climates, and ranging from wetland to desert regions. A greater salamander averages three meters, nose to tail, but have been recorded as large as eight. Extremely fireproof, these creatures exude a highly flammable mucous that they seem to be able to ignite at will. This slime is highly valued by alchemists.
Salamander, Lesser: a wetland dwelling amphibian ranging in size from that of a wolf to matching that of an adult Uruk. Lesser salamanders do not themselves generate fire, though they are highly fire resistant. They do however produce copious amounts of methane gas in their digestive tract, which they release when threatened or hunting. This in turn attracts pyreflies, and shortly thereafter, explosions.
Sandtrap: Legend tells of an exceptionally foolish adventurer who found a Spring of the Mist in some ruins in the EastFyre Desert, and stuck his head in. For his troubles, he was transformed into the first of the Sandtraps: barely sentient hermaphroditic ant-lion-taurs with a penchant for injecting eggs into the innards of their victims and sending them on their way. If you're lucky, they'll use the existing aperture to do this.
Sathar: also known as burrowing hydras. Resembling a one-to-two ton earthworm with three heads, these creatures are toxic if ingested, have corrosive saliva, three tongues per head, and use sufficient suction to consume their prey that they can suck out your internal organs through your navel. And can regrow most missing body parts in a day, sometimes leading to you having two or more Sathar to deal with the next day.
Serpent, Giant: Any snake taller than you are when laying flat. Fortunately, as with real world large snakes, giant serpents are all constrictors. Except the talking ones: those tend to venomous, and have grudges against other epic creatures, frequently dragons, drakes, and Sun Giants.
Sheep: Wool. Mutton. Bad jokes about shepherds.
Shoushou: Demons who have been bound into weapons. The Order of the Shoushou Knights is the major modern source of such tools. The concept is that the power of a demon can be used constructively by a good individual with sufficient will, and eventually, the entity can be redeemed. The historical track record for that last part is low, but non-zero.
Skeleton, Animated: The result of the bread-and-butter enchantment of professional necromancers: some creature's skeleton that can move about on its own. Depending on the needs of the enchanter, they can be adequately competent warriors, housemaids, or even tailors. They have an irritating tendency to outlast their owners.
Skeleton, Argonian: Advanced warrior skeletons. Usually equipped with a shield that resembles a smaller creature's rib cage, and a hand weapon (club, scimitar, or spear) also apparently made of bone. Argonian skeletons will quite willingly throw their own ribs at you, boomerang style, and yes, they do come back.
Skull Sheep: An undead monster native to Lallybroch and the Tikume Plains. Apparently a solid mass of bones, this creature is covered by a dark colored hide that obscures the body whilst the head seems almost luminescent in the moonlight. Skull sheep can spit varying sized bone chunks at its enemies as an attack, ranging from a single pointed femur to a spray of chips. Like most undead, nocturnal, though most are uncertain where they lair up during the day.
Slime: On par with “large rats” in danger level. A gelatinous creature about the size of a rugby ball that normally subsists on decaying organic matter. Slimes are somewhat corrosive on contact, highly resistant to blunt or slashing attacks, and weak to piercing, water, or ice attacks. If you are accurate enough to target the “core” in the middle, you can usually one-shot a slime. However, the only part of them that has any value is the core. Every generation some idiot tries to breed better slimes, leading to the Mercenaries Guild vigorously suppressing their work before madness takes hold and they develop Cloth Devouring Slimes.
Slime, Brown: A somewhat domesticated breed of slime commonly found at the bottom of your privy. They turn people's waste into water and more slimes with great efficiency. Most major towns and nearly all cities will have professional services to collect your excess brown slimes, and sell their cores to alchemists towards the manufacture of deodorizing sachets.
Snow Lion: A huge breed of sea lion that re-adapted for land. Its forelimbs have huge claws, its tail is lengthened, and it has a dorsal line of spikes running from its head to its tail tip. If its prey becomes too uncooperative, it will use Ice Breath.
Spidersnake: A ten-eyed, eight-legged venomous serpent native to the Burninglass Desert. Spidersnakes can change their coloration to match their environment, and the glandular secretion that allows this is extremely valuable. Distilled, the substance can permanently change eye color.
Stiltgeist: A coastal wetlands creature, thankfully solitary in nature. A frustratingly durable crustacean with a main body about twenty feet across. It shuffles around its territory on four, 200-300' long legs with a disturbing number of knees. Stiltgeists are carnivores, and hunt by retracting one clawed foot up to its body, then stomping on whatever attracted its attention, then bringing the corpse up to the mouth on its abdomen. It has been centuries since anyone has managed to knock one over like Luke Skywalker and the AT-AT. The Blackstone Company got one by enchanting a cow with a massive, time-delayed fireball spell.
Stirge: Bat like creatures about the size of a hawk with a long, needle sharp beak. Stirges feed exclusively on blood, and a single stirge will consume about a half pint before being sated. They can get most of that in a single attack, and work well in flocks. Their saliva contains a natural anti-coagulant, and they hunt primarily by smell. The beaks fetch a good price with alchemists.
Sulokil: A multi-ton herbivore that resembles a hybrid between a rhinoceros and a triceratops, with bonus bony knobs protruding from seemingly arbitrary parts of its body. Sulokil are largely docile, have excellent Darkvision and hearing, and are frequently domesticated by Dwarven Halls.
Sword Stag: An omnivorous creature the size of a light horse resembling a deer, native to the Camwood. The beast has scimitar-like blades emerging from the sides of its skull that are lethally sharp. Sword Stags are preemptively territorial, and will attempt to kill any creature the size of a dwarf or larger. Fortunately, males over the age of one also don't get along, limiting their populations. Their horns are valued by Elves, enchanters, and chiton-crafters.